abstract：:In 1989, 65%-75% of previously untreated adults with ALL or AML may be expected to enter complete remission. Approximately 40% of these completely responding patients, whether they are treated with intensive chemotherapy, intensive chemotherapy followed by autologous bone marrow transplantation, or allogeneic bone mar...

journal_title：Journal of cancer research and clinical oncology

authors： Mayer RJ

更新日期：1990-01-01 00:00:00

abstract：:In addition to spontaneous uterine endometrial adenocarcinomas at a high incidence (35.1%), development of endometrial hyperplasia/adenoma was also frequently detected in rats of the Donryu strain. The total yield of all observed proliferative endometrial lesions was very high (60.6%). The tumors arose commonly in the...

journal_title：Journal of cancer research and clinical oncology

authors： Nagaoka T,Onodera H,Matsushima Y,Todate A,Shibutani M,Ogasawara H,Maekawa A

更新日期：1990-01-01 00:00:00

abstract：:The regulatory influence of medroxyprogesterone acetate (MPA) on estrogen and androgen receptors of the human breast cancer cell lines MCF-7 and EFM-19 was explored in conjunction with the growth-promoting properties of these steroids. In the absence of steroidal stimulation, up to 1 microM MPA had no effect on the pr...

journal_title：Journal of cancer research and clinical oncology

authors： Hackenberg R,Hofmann J,Wolff G,Hölzel F,Schulz KD

更新日期：1990-01-01 00:00:00

abstract：:The purpose of this study was to examine the structure/activity relationships of a series of substituted benzamides as poly(ADP-ribose) polymerase inhibitors. The experimental approach has involved the use of in vitro and in vivo assays in order to gather information either on the intrinsic activity of the benzamides ...

journal_title：Journal of cancer research and clinical oncology

authors： Sestili P,Spadoni G,Balsamini C,Scovassi I,Cattabeni F,Duranti E,Cantoni O,Higgins D,Thomson C

更新日期：1990-01-01 00:00:00

abstract：:Altered and deregulated cellular oncogenes were found in many human solid tumors. Except for a few types of tumors that consistently exhibited specific altered proto-oncogenes, the majority of tumors are associated with a number of transcriptionally activated cellular oncogenes. In the heterologous group of non-small-...

journal_title：Journal of cancer research and clinical oncology

authors： Kiefer PE,Wegmann B,Bacher M,Erbil C,Heidtmann H,Havemann K

更新日期：1990-01-01 00:00:00

abstract：:The effect of growth phase on enzymatic activities of the de novo and salvage pathways for purine and pyrimidine nucleotide synthesis was studied in a hepatocyte-derived cell line from the rat. The cells were in lag phase after plating for 36 h; log phase started at 48 h and persisted up to 120 h of culture. Then the ...

journal_title：Journal of cancer research and clinical oncology

authors： Mayer D,Natsumeda Y,Ikegami T,Faderan M,Lui M,Emrani J,Reardon M,Oláh E,Weber G

更新日期：1990-01-01 00:00:00

abstract：:Using batroxobin, a thrombin-like enzyme found in snake venom, the effects of defibrinogenation on artificial lung metastasis in mice were studied. The role of natural killer (NK) cells in the inhibitory effects of defibrinogenation on metastasis was also investigated. Artificial lung metastasis experiments were perfo...

journal_title：Journal of cancer research and clinical oncology

authors： Shibuya M,Niitani H,Aoyama A,Kawachi S,Nukariya N,Baba M,Iizuka K,Sakai S,Ohtsuka M

更新日期：1990-01-01 00:00:00

abstract：:DNA repair is an important process. It is as essential for the cell as is transcription and replication. There is evidence that deficient DNA repair processes lead to human disease including cancer, and recent progress in the field of DNA repair is likely to expand our knowledge about these relationships considerably....

journal_title：Journal of cancer research and clinical oncology

authors： Bohr VA

更新日期：1990-01-01 00:00:00

abstract：:To examine the relationship between altered spontaneous mutation rates and malignant characteristics of cells, two hydroxyurea-resistant Chinese hamster ovary cell lines, with alterations in ribonucleotide reductase, were examined for their rates of spontaneous mutation to 6-thioguanine and ouabain resistance, tumor g...

journal_title：Journal of cancer research and clinical oncology

authors： Tagger AY,Damen JE,Greenberg AH,Wright JA

更新日期：1989-01-01 00:00:00

abstract：:(alpha 1----3)-L-Fucosyltransferase activity was measured in serum samples from 90 gastric cancer patients, 10 patients with benign diseases and 100 healthy controls. The enzyme activity was significantly elevated in the serum samples of patients with cancer compared to those from patients with benign diseases (P less...

journal_title：Journal of cancer research and clinical oncology

authors： Yazawa S,Asao T,Nagamachi Y,Abbas SA,Matta KL

更新日期：1989-01-01 00:00:00

abstract：:The highly metabolized nitrosourea carmustine (BCNU) is an anticancer agent which alkylates DNA and is metabolized to both active and inactive species by cytochrome P-450 enzymes. Other highly metabolized anticancer drugs have altered toxicities when some histamine H2 antagonists are coadministered. To test this hypot...

journal_title：Journal of cancer research and clinical oncology

authors： Dorr RT,Soble MJ

更新日期：1989-01-01 00:00:00

abstract：:In this study we investigated the presence of epidermal growth factor receptors (EGF-R) and the tissue levels of EGF-like factors (EGF-F) in ovarian, endometrial, cervical and breast carcinomas. EGF-R were found in 33/40 (83%) cervical, 15/26 (58%) endometrial, 64/141 (45%) ovarian, and 19/59 (33%) breast carcinomas. ...

journal_title：Journal of cancer research and clinical oncology

authors： Bauknecht T,Kohler M,Janz I,Pfleiderer A

更新日期：1989-01-01 00:00:00

abstract：:Two cell clones of a methylnitrosourea-induced rat mammary carcinoma, a hyperdiploid (44 chromosomes, clone A) and a hypertetraploid clone (88 chromosomes, clone B) were cultured and transplanted subcutaneously into three groups of eight rats. Group 1 was treated with 62.6 mg cyclophosphamide/kg, group 2 with 41.8 mg/...

journal_title：Journal of cancer research and clinical oncology

authors： Angres G,Scherf HR

更新日期：1989-01-01 00:00:00

abstract：:Several investigators have discussed the possible combination of tamoxifen and interferon (IFN) in the treatment of breast cancer patients. The rationale in combining these drugs is that IFN induces the expression of estrogen receptors and therefore increases the sensitivity of breast cancer cells toward the growth-in...

journal_title：Journal of cancer research and clinical oncology

authors： Porzsolt F,Otto AM,Trauschel B,Buck C,Wawer AW,Schönenberger H

更新日期：1989-01-01 00:00:00

abstract：:Unstimulated and interferon (IFN)-stimulated natural killer cell (NK) activity was investigated in patients with malignant melanoma prior to the removal of the primary melanoma (stage I disease) or in patients with melanoma metastases. Unstimulated as well as IFN-stimulated NK activities, directed against the primaril...

journal_title：Journal of cancer research and clinical oncology

authors： Müller C,Pehamberger H,Binder M,Zielinski CC

更新日期：1989-01-01 00:00:00

abstract：:Human breast carcinomas were evaluated for estrogen and progesterone receptors by immunohistochemistry using monoclonal anti-receptor antibodies (n = 267) and by cytosol steroid-binding assays (n = 212). The estrogen and progesterone receptor contents of the tumors correlated with histological features of differentiat...

journal_title：Journal of cancer research and clinical oncology

authors： Helle M,Helin M,Isola J,Helin H

更新日期：1989-01-01 00:00:00

abstract：:To verify whether a mild, but prolonged liver injury by chemicals needing bioactivation causes both hepatic cirrhosis and the appearance of hepatocyte nodules and tumors (providing the liver has been exposed previously to initiating stimuli), diethylnitrosamine-initiated and uninitiated rats were administered thioacet...

journal_title：Journal of cancer research and clinical oncology

authors： Gervasi PG,Longo V,Marzano M,Saviozzi M,Malvaldi G

更新日期：1989-01-01 00:00:00

abstract：:Antinucleolar antisera were raised in rabbits, goats and sheep to nucleoli isolated from three human tumor cell lines. The antisera were shown to cross-react by immunofluorescence with human tumor cell lines originating from different organs and with frozen sections from a wide variety of human malignant and non-malig...

journal_title：Journal of cancer research and clinical oncology

authors： Greenfield RS,Lamon MO,Olech LJ,Grattan JA

更新日期：1989-01-01 00:00:00

abstract：:Two human melanoma xenografts were compared with respect to their in vivo growth and metastatic potentials as well as glycosaminoglycan patterns. The less differentiated HT 168 tumor showed faster growth at primary sites and a more pronounced capacity for metastasis into the liver. Although chondroitin sulfate was the...

journal_title：Journal of cancer research and clinical oncology

authors： Timár J,Kovalszky I,Paku S,Lapis K,Kopper L

更新日期：1989-01-01 00:00:00

abstract：:We measured an estrogen-receptor-associated protein (ER-D5), estrogen and progesterone receptors (ER; PgR) in samples obtained from 28 female patients with primary breast carcinoma. A correlation of r = 0.79 was found between ER-D5 and ER values and between ER-D5 and PgR values in premenopausal woman. In postmenopausa...

journal_title：Journal of cancer research and clinical oncology

authors： Navarro MA,Guardia M,Arranz B,Bonnin MR,Rosel P

更新日期：1989-01-01 00:00:00

abstract：:This study was undertaken in order to compare the usefulness of three indices of tumour proliferation in detecting primary hepatocellular carcinoma (HCC) and in differentiating this neoplasm from liver cirrhosis. In 10 patients with HCC and in 63 with liver cirrhosis serum alpha-fetoprotein (AFP), tissue polypeptide a...

journal_title：Journal of cancer research and clinical oncology

authors： Leandro G,Basso D,Fabris C,Zizzari S,Elba S,Del Favero G,Di Mario F,Meggiato T,Angonese C,Naccarato R

更新日期：1989-01-01 00:00:00

abstract：:Female rats aged 3 months and 15 months each received a single i.v. administration of N-nitrosomethylurea (NMU) at one of three doses: 10, 20, and 50 mg/kg. The rats exposed to NMU at the age of 3 months developed neoplasms of all sites examined, including mammary carcinomas and tumors of the kidney, ovaries and colon...

journal_title：Journal of cancer research and clinical oncology

authors： Anisimov VN

更新日期：1988-01-01 00:00:00

abstract：:Male Sprague-Dawley rats were treated for 7 weeks with 120 mg/l N-nitrosomorpholine in their drinking water. At the end of the treatment period there were large numbers of enzyme-altered foci in the liver. During the following 10 weeks, the number of foci decreased significantly. This decrease in the number of enzyme-...

journal_title：Journal of cancer research and clinical oncology

authors： Enzmann H,Bannasch P

更新日期：1988-01-01 00:00:00

abstract：:Synergy of folinic acid and FU has been shown in several experimental systems. In the present study we examined the kinetics of concurrent administration of folinic acid on the kinetics of FU in an in vivo model. Folinic acid significantly increased the amount of FU bound to the TS complex. In the sequential combinati...

journal_title：Journal of cancer research and clinical oncology

authors： Herrmann R,Reuter J,Port R,Osswald H

更新日期：1988-01-01 00:00:00

abstract：:Sarcoma 180 tumor tissue from C57 mice was processed in a soft agar clonogenic assay immediately after removal from the animal and after various methods of storage. The sensitivity to the antineoplastic drug cis-platinum was not affected by different storage methods. The highest yield of colony forming cells per 100 m...

journal_title：Journal of cancer research and clinical oncology

authors： Krischke W,Hartmann R,Schneider M,Schönenberger H

更新日期：1988-01-01 00:00:00

abstract：:In the present study, we report that the betel quid ingredient catechu, its extract and pure principle catechin were nonmutagenic in Salmonella typhimurium TA 100, TA 1535, TA 98, and TA 1538 assays with or without metabolic activation. They also exhibited dose-dependent decreases in mutagenicity of benzo(a)pyrene [B(...

journal_title：Journal of cancer research and clinical oncology

authors： Nagabhushan M,Maru GB,Amonkar AJ,Nair UJ,Santhanam U,Ammigan N,D'Souza AV,Bhide SV

更新日期：1988-01-01 00:00:00

abstract：:Cases of cancer notified to the Danish Cancer Registry during the period 1970 to 1984 in the age groups 16 to 66 years have been linked to information on employment kept on file in the nationwide Supplementary Pension Fund since 1964. Industrial hygienists classified industrial groups as defined by the Pension Fund wi...

journal_title：Journal of cancer research and clinical oncology

authors： Olsen JH,Møller H,Jensen OM

更新日期：1988-01-01 00:00:00

abstract：:Bromelain, a pineapple-derived plant product, added to C57Bl/6 mice laboratory chow decreased lung metastasis of Lewis lung cancer cells implanted s.c. This antimetastatic potential was demonstrated by both the active and inactive bromelain with or without proteolytic, anticoagulant properties. ...

journal_title：Journal of cancer research and clinical oncology

authors： Batkin S,Taussig SJ,Szekerezes J

更新日期：1988-01-01 00:00:00

abstract：:Antibody-toxin conjugates, termed immunotoxins, are currently being evaluated as potential new anticancer agents. The monoclonal antibodies that recognize antigens on the surface of tumor cells should deliver the toxins or the catalytic subunits of toxins to cancer cells. The catalytically active parts of the immunoto...

journal_title：Journal of cancer research and clinical oncology

authors： Pirker R

更新日期：1988-01-01 00:00:00

abstract：:Chinese hamster ovary cells were heated for 20 min at 45.5 degrees C in different conditions, and quantitative determinations of cellular membrane blebbing were performed for cells maintained at 25 degrees C and 37 degrees C after hyperthermia. The percentage of cells with blebs following heating was dependent upon th...

journal_title：Journal of cancer research and clinical oncology

authors： Kapiszewska M,Hopwood LE

更新日期：1988-01-01 00:00:00

abstract：:Elevated glutamate concentrations are commonly observed in tumor patients, and glutamate was recently found to competitively inhibit the membrane transport of cystine. We therefore investigated the possibility that elevated plasma glutamate levels may damage the immune system. The experiments in this report demonstrat...

journal_title：Journal of cancer research and clinical oncology

authors： Dröge W,Eck HP,Betzler M,Schlag P,Drings P,Ebert W

更新日期：1988-01-01 00:00:00

abstract：:A continuous line of human breast carcinoma cells, VHB-1, was established in culture following collagenase treatment of an infiltrating duct cell carcinoma. The cells displayed an epithelial pattern and multiplied rapidly. Maintained in monolayer culture, the VHB-1 cells exhibited a 30-h doubling time and a plating ef...

journal_title：Journal of cancer research and clinical oncology

authors： Vandewalle B,Collyn d'Hooghe M,Savary JB,Vilain MO,Peyrat JP,Deminatti M,Delobelle-Deroide A,Lefebvre J

更新日期：1987-01-01 00:00:00

abstract：:Formaldehyde is a reactive chemical which undergoes spontaneous reactions with various cellular constituents. Mutagenicity data may be interpreted on the background of this behavior. Mice are better able to reduce the irritating effect of formaldehyde than rats and to reduce their ventilation rate when formaldehyde ac...

journal_title：Journal of cancer research and clinical oncology

authors： Bolt HM

更新日期：1987-01-01 00:00:00

abstract：:Nitrosodiphenylamine was tested for induction of DNA single strand breaks in rat hepatocytes and Chinese hamster V 79 cells with the alkaline filter elution assay. While in rat hepatocytes DNA damage was observed, negative results were obtained in V 79 cells. In view of the metabolic capacity of hepatocytes and the ch...

journal_title：Journal of cancer research and clinical oncology

authors： Appel KE,Görsdorf S,Scheper T,Ruf HH,Rühl CS,Hildebrandt AG

更新日期：1987-01-01 00:00:00

abstract：:A new experimental method to test the effect of drugs on tumor-induced osteolysis using a bladder tumor in mice has been designed. The method consisted of inoculating MBT-2 tumor cells s.c. over the calvaria in mice, resulting in a local tumor causing fragmentation of the bone. This was accompanied by adjacent osteopl...

journal_title：Journal of cancer research and clinical oncology

authors： Nemoto R,Uchida K,Tsutsumi M,Koiso K,Satou S,Satou T

更新日期：1987-01-01 00:00:00

abstract：:G2-enriched fractions of Ehrlich ascites tumor cells (up to 80%-85% G2 cells) separated from anaerobically and aerobically cultured asynchronous populations by centrifugal elutriation revealed the same growth characteristics after recultivation under standard conditions: a significant proportion of cells with increase...

journal_title：Journal of cancer research and clinical oncology

authors： Kroll C,Schneider F

更新日期：1987-01-01 00:00:00

abstract：:The XP cell strain XP29MA, its malignant counterpart XP29MAmal and a normal human fibroblast strain were tested for colony-forming ability after treatment with HECNU in the presence of m6G, m6Gua, and he7G. In XP29MAmal, inhibition of post-HECNU colony-forming ability was 35% when 0.25 mM of either m6G or m6Gua were p...

journal_title：Journal of cancer research and clinical oncology

authors： Thielmann HW,Edler L,Müller N,Eisenbrand G

更新日期：1987-01-01 00:00:00

abstract：:To date, all risk assessment studies on benzene have been based almost exclusively on epidemiological data. We have attempted a more integrated and quantitative evaluation of carcinogenic risk for humans, trying to utilize, in addition to the epidemiological data, all data available, specifically data on metabolism, g...

journal_title：Journal of cancer research and clinical oncology

authors： Grilli S,Lutz WK,Parodi S

更新日期：1987-01-01 00:00:00

abstract：:Bis-beta-diketonato complexes of titanium, zirconium, and hafnium were tested against autochthonous colorectal tumors in rats. The model was found to reflect the clinical situation most closely. Of the compounds tested, budotitane was the most effective in terms of decrease in tumor weight and number and in increasing...

journal_title：Journal of cancer research and clinical oncology

authors： Bischoff H,Berger MR,Keppler BK,Schmähl D

更新日期：1987-01-01 00:00:00

abstract：:The chemotherapeutic action of tegafur (FT) against adenocarcinoma 755 in mice was markedly potentiated by oral administration of L-cysteine and L-cystine without increasing its toxicity. In particular, the combination of FT at 200 mg/kg per day (maximum dose) and 1000 mg/kg per day of L-cystine markedly inhibited tum...

journal_title：Journal of cancer research and clinical oncology

authors： Iigo M,Hoshi A,Kitagawa H

更新日期：1986-01-01 00:00:00